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主营：抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
℡ 4000-520-616
℡ 4000-520-616
StressMarq/Alpha Synuclein Protein/SPR-316C/200-µg
产品编号：SPR-316C
市  场 价：¥10880.00
场      地：美国(厂家直采)
产品分类： 生化试剂>其他>酚>
联系QQ：1570468124
电话号码：4000-520-616
邮      箱： info@ebiomall.com
美  元  价：$544.00
品      牌： StressMarq
公      司：StressMarq
公司分类：
StressMarq/Alpha Synuclein Protein/SPR-316C/200-µg
商品介绍

Overview:

ProductNameAlphaSynucleinProtein
Description

HumanRecombinantAlphaSynucleinProteinMonomer(Control)

ApplicationsWB,SDS-PAGE,Invivoassay,Invitroassay
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesNotag

Properties

StorageBuffer0.2µmfilteredsolutionin20mMtris,150mMNaClpH7.5
StorageTemperature-80ºC
ShippingTemperatureBlueIceor4ºC
PurificationIon-exchangePurified
Specificity~14.46kDa
CiteThisProductHumanRecombinantAlphaSynucleinProtein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-316)
CertificateofAnalysisCertified92%pureusingSDS-PAGEanalysis.

BIOLOGicalDescription

AlternativeNamesAlphasynucleinmonomer,Alpha-synucleinmonomer,Alphasynucleinproteinmonomer,Alphasynucleinmonomer,Alpha-synucleinprotein,Non-AbetacomponentofADamyloidprotein,Non-A4componentofamyloidprecursorprotein,NACPprotein,SNCAprotein,NACPprotein,PARK1protein,Alphasynucleinmonomers,SYNprotein,Parkisondiseasefamilial1Protein
ResearchAreasAlzheimer"sDisease,Neurodegeneration,Neuroscience,Parkinson"sDisease
CellularLocalizationCytoplasm,Membrane,Nucleus
AccessionNumberNP_000336.1
GeneID6622
SwissProtP37840
ScientificBackgroundAlpha-Synuclein(SNCA)isexpressedpredominantlyinthebrain,whereitisconcentratedinpresynapticnerveterminals(1).Alpha-synucleinishighlyexpressedinthemitochondriaoftheolfactorybulb,hippocampus,striatumandthalamus(2).Functionally,ithasbeenshowntosignificantlyinteractwithtubulin(3),andmayserveasapotentialmicrotubule-associatedprotein.Ithasalsobeenfoundtobeessentialfornormaldevelopmentofthecognitivefunctions;inactivationmayleadtoimpairedspatiallearningandworkingmemory(4).SNCAfibrillaraggregatesrepresentthemajornonA-betacomponentofAlzheimersdiseaseamyloidplaque,andamajorcomponentofLewybodyinclusions,andParkinson’sdisease.Parkinson"sdisease(PD)isacommonneurodegenerativedisordercharacterizedbytheprogressiveaccumulationinselectedneuronsofproteininclusionscontainingalpha-synucleinandubiquitin(5,6).
References1.“GeneticsHomeReference:SNCA”.USNationalLibraryofMedicine.(2013).
2.ZhangL.,etal.(2008)BrainRes.1244:40-52.
3.AlimM.A.,etal.(2002)JBiolChem.277(3):2112-2117.
4.KokhanV.S.,AfanasyevaM.A.,Van’kinG.(2012)Behav.Brain.Res.231(1):226-230.
5.SpillantiniM.G.,etal.(1997)Nature.388(6645):839-840.
6.MezeyE.,etal.(1998)NatMed.4(7):755-757.

ProductImages

<p>SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Monomer (Control) (SPR-316). Lane 1: Molecular Weight Ladder (MW). Lane 2: BSA (2.5 µg). Lane 3: BSA (5 µg). Lane 4: Alpha Synuclein Protein Monomer (2.5 µg) (SPR-316). Lane 5: Alpha Synuclein Protein Monomer (5 µg) (SPR-316).</p>

SDS-PAGEof~14kDaHumanRecombinantAlphaSynucleinProteinMonomer(Control)(SPR-316).Lane1:MolecularWeightLadder(MW).Lane2:BSA(2.5µg).Lane3:BSA(5µg).Lane4:AlphaSynucleinProteinMonomer(2.5µg)(SPR-316).Lane5:AlphaSynucleinProteinMonomer(5µg)(SPR-316).

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to when 100 µM of control alpha Synuclein monomer (SPR-316) is combined with 10 nM of active alpha Synuclein aggregate (SPR-322). Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtowhen100µMofcontrolalphaSynucleinmonomer(SPR-316)iscombinedwith10nMofactivealphaSynucleinaggregate(SPR-322).ThioflavinTex=450nm,em=485nm.

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to active alpha Synuclein aggregate (SPR-322) and active alpha Synuclein monomer (SPR-321) alone. Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtoactivealphaSynucleinaggregate(SPR-322)andactivealphaSynucleinmonomer(SPR-321)alone.ThioflavinTex=450nm,em=485nm.

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to when 100 µM of active alpha Synuclein monomer (SPR-321) is combined with 10 nM of control alpha Synuclein aggregate (SPR-317), or 100 µM of control alpha Synuclein monomer (SPR-316) is combined with 10 nM of control alpha Synuclein aggregate (SPR-317). Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtowhen100µMofactivealphaSynucleinmonomer(SPR-321)iscombinedwith10nMofcontrolalphaSynucleinaggregate(SPR-317),or100µMofcontrolalphaSynucleinmonomer(SPR-316)iscombinedwith10nMofcontrolalphaSynucleinaggregate(SPR-317).ThioflavinTex=450nm,em=485nm.

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to when 100 µM of control alpha Synuclein monomer (SPR-316) is combined with 10 nM of active alpha Synuclein aggregate (SPR-322), or active alpha Synuclein aggregate (SPR-322) and active alpha Synuclein monomer (SPR-321) alone. Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtowhen100µMofcontrolalphaSynucleinmonomer(SPR-316)iscombinedwith10nMofactivealphaSynucleinaggregate(SPR-322),oractivealphaSynucleinaggregate(SPR-322)andactivealphaSynucleinmonomer(SPR-321)alone.ThioflavinTex=450nm,em=485nm.

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品牌介绍

    StressMarq Biosciences Inc.位于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究。我们有强大的国际经销商网络，主要为私人和公众客户提供经我们多次试验成功的试剂，服务范围遍及全球40多个国家。 我们公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。 通过定位好以上四个领域，研究人员能够运用研究相关的整套试剂工具，将研究产品重点放在热休克蛋白70和90（HSP70和HSP90）两个核心领域。产品主要包括ELISA试剂盒、抑制剂、蛋白质（包括无内毒素制剂，而非低内毒素制剂）以及经过高级验证的抗体，产品在全球范围内均有销售。 StressMarq因其试剂验证质量过硬，跻身为高端公司。研究人员能放心使用抗体产品，因为本产品将具有免疫印迹（WB）、免疫沉淀、组织染色技术的功能，如免疫组织化学（IHC）和免疫细胞化学（ICC）。 本公司提供氧化应激产品，如8OHdG（DNA受损）ELISA试剂盒，同时还提供专门的抗体，适用于非定量技术，如免疫组化。在免疫组化中，组织的目标可视化更为重要。除了提供用于进一步研究的相关工具外，StressMarq还提供新的尖端研究工具，用于开发新的生物项目，包括全球独一无二的α B晶体蛋白ELISA试剂盒（现在是公认的乳腺癌标志物）以及热休克同源蛋白70（Hsc70）ELISA试剂盒。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域，前者包括当前热门的核心领域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括当前热门的核心领域：ENaC、NCC和NKCC2以及主要水通道蛋白载体。

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