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主营:抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒
℡ 4000-520-616
℡ 4000-520-616
StressMarq/Anti-ErbB2 Antibody (pTyr735)/SPC-968D-A390/100-µl
产品编号:SPC-968D-A390
市  场 价:¥6860.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$343.00
品      牌: StressMarq
公      司:StressMarq
公司分类:
StressMarq/Anti-ErbB2 Antibody (pTyr735)/SPC-968D-A390/100-µl
商品介绍

Overview:

Product Name ErbB2 Antibody (pTyr735)
Description

Rabbit Anti-Human ErbB2 (pTyr735) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Tyr735 of human ErbB2 (AA732-739)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 137.91 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-968, RRID: AB_2707823
Certificate of Analysis A 1:250 dilution of SPC-968 was sufficient for detection of ErbB2 (pTyr735) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names ER Alpha antibody, ER Beta antibody, Era antibody, Erb antibody, Erb2 antibody, ESR antibody, ESR1 antibody, ESR1_HUMAN antibody, ESR2 antibody, ESRA antibody, ESRB antibody, Estr antibody, Estra antibody, Estradiol Receptor alpha antibody, ESTRB antibody, Estrogen receptor 1 (alpha) antibody, Estrogen Receptor 1 antibody, Estrogen receptor 2 (ER beta) antibody, NR3A1 antibody, NR3A2 antibody, Nuclear receptor subfamily 3 group A member 1 antibody, Nuclear receptor subfamily 3 group A member 2 antibody, RNESTROR antibody
Research Areas Cancer, Cell Signaling, Oncoproteins, Protein Phosphorylation, Receptor Tyrosine Kinases, Serine / Threonine Kinases, Tumor Biomarkers, Tyrosine Kinases
Cellular Localization Cytoplasm, Cell membrane, Nucleus
Accession Number NP_004439
Gene ID 2064
Swiss Prot P04626
Scientific Background ErbB2 is a receptor-tyrosine kinase of the epidermal growth factor receptor family,that is activated upon binding NRG with ErbB3. NRG acts as an autocrine factor produced in ovarian carcinomas. ERBB2 needs a coreceptor for ligand binding. Activates MAPK and PI3K pathways and is involved in cell proliferation, prolonging and enhancing survival signals, differentiation and apoptosis. Amplification and overexpression of ERBB2 is associated with numerous cancers. The increase of ERBB2 protein in breast tumour can be up to 100-fold.

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  ATTO 390
Overview:

  • High fluorescence yield
  • Large Stokes-shift (89 nm)
  • Good photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Coumarin derivate, uncharged
  • Low molar mass: 343.42 g/mol 

ATTO 390 Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission SpectraOptical Properties:

λex = 390 nm

λem = 479 nm

εmax = 2.4×104

Φf = 0.90

τfl = 5.0 ns

Brightness = 21.6

Laser = 365 or 405 nm

 

品牌介绍

    StressMarq Biosciences Inc.位于加拿大维多利亚,是一家生物科技公司,专门从事试剂与试剂盒研究。我们有强大的国际经销商网络,主要为私人和公众客户提供经我们多次试验成功的试剂,服务范围遍及全球40多个国家。 我们公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。 通过定位好以上四个领域,研究人员能够运用研究相关的整套试剂工具,将研究产品重点放在热休克蛋白70和90(HSP70和HSP90)两个核心领域。产品主要包括ELISA试剂盒、抑制剂、蛋白质(包括无内毒素制剂,而非低内毒素制剂)以及经过高级验证的抗体,产品在全球范围内均有销售。 StressMarq因其试剂验证质量过硬,跻身为高端公司。研究人员能放心使用抗体产品,因为本产品将具有免疫印迹(WB)、免疫沉淀、组织染色技术的功能,如免疫组织化学(IHC)和免疫细胞化学(ICC)。 本公司提供氧化应激产品,如8OHdG(DNA受损)ELISA试剂盒,同时还提供专门的抗体,适用于非定量技术,如免疫组化。在免疫组化中,组织的目标可视化更为重要。除了提供用于进一步研究的相关工具外,StressMarq还提供新的尖端研究工具,用于开发新的生物项目,包括全球独一无二的α B晶体蛋白ELISA试剂盒(现在是公认的乳腺癌标志物)以及热休克同源蛋白70(Hsc70)ELISA试剂盒。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域,前者包括当前热门的核心领域:Nav、Cav、TRP、Kv、KCNQ、HCN,后者包括当前热门的核心领域:ENaC、NCC和NKCC2以及主要水通道蛋白载体。

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