StressMarq/HSP90 alpha Protein/SPR-101C/2x100-µg,StressMarq,,StressMarq,StressMarq Biosciences,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：StressMarq/HSP90 alpha Protein/SPR-101C/2x100-µg

产品编号：SPR-101C

市场价：¥6580.00

场地：美国(厂家直采)

产品分类：生化试剂>缓冲液>酸碱缓冲液>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$329.00

品牌： StressMarq

公司：StressMarq

公司分类：

商品介绍

Overview:

ProductName HSP90alphaProtein

Description

HumanRecombinantHSP90alphaProtein

Applications WB,SDS-PAGE,ATPaseActivityAssay,SurfacePlasmonResonance(SPR)

Concentration Lot/batchspecific.Seeincludeddatasheet.

Conjugates

Notag

Properties

StorageBuffer	50mMTris/HClpH7.5,5mMBme,0.3MNaCl,10%glycerol
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	AffinityPurified
Specificity	~90kDa
CiteThisProduct	HumanRecombinantHSP90alphaProtein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-101)
CertificateofAnalysis	Thisproducthasbeencertified>90%pureusingSDSPAGEanalysis.

BIOLOGicalDescription

AlternativeNames	HSP86Protein,HSP89AProtein,HSP90AProtein,HSP90AA1Protein,HSPC1Protein,HSPCAProtein,HSPCAL3Protein,HSP90alphaProtein
ResearchAreas	Cancer,HeatShock
CellularLocalization	Cytoplasm,Melanosome
AccessionNumber	AJ890083
GeneID	3320
SwissProt	P0790,P07900
ScientificBackground	HSP90isahighlyconservedandessentialstressproteinthatisexpressedinalleukaryoticcells.Fromafunctionalperspective,HSP90participatesinthefolding,assembly,maturation,andstABIlizationofspecificproteinsasanintegralcomponentofachaperonecomplex(1-4).Despiteitslabelofbeingaheat-shockprotein,HSP90isoneofthemosthighlyexpressedproteinsinunstressedcells(1–2%ofcytosolicprotein).Itcarriesoutanumberofhousekeepingfunctions–includingcontrollingtheactivity,turnover,andtraffickingofavarietyofproteins.MostoftheHSP90-regulatedproteinsthathavebeendiscoveredtodateareinvolvedincellsignaling(5-6).ThenumberofproteinsnowknowtointeractwithHSP90isabout100.Targetproteinsincludethekinasesv-Src,Wee1,andc-Raf,transcriptionalregulatorssuchasp53andsteroidreceptors,andthepolymerasesofthehepatitisBvirusandtelomerase.5.WhenboundtoATP,HSP90interactswithco-chaperonesCdc37,p23,andanassortmentofimmunophilin-likeproteins,formingacomplexthatstabilizesandprotectstargetproteinsfromproteasomaldegradation.Inmostcases,HSP90-interactingproteinshavebeenshowntoco-precipitatewithHSP90whencarryingoutimmunoadsorptionstudies,andtoexistincytosolicheterocomplexeswithit.Inanumberofcases,variationsinHSP90expressionorHSP90mutationhasbeenshowntodegradesignalingfunctionviatheproteinortoimpairaspecificfunctionoftheprotein(suchassteroidbinding,kinaseactivity)invivo.Ansamycinantibiotics,suchasgeldanamycinandrADIcicol,inhibitHSP90function(7).LookingformoreinformationonHSP90?VisitournewHSP90ScientificResourceGuideathttp://www.HSP90.ca.
References	1.ArlanderS.J.H.,etal.(2003)JBiolChem.278:52572-52577. 2.PearlH.,etal.(2001)AdvProteinChem.59:157-186. 3.NeckersL.,etal.(2002)TrendsMolMed.8:S55-S61. 4.PrattW.,ToftD.(2003)ExpBiolMed.228:111-133. 5.PrattW.,ToftD.(1997)EndocrRev.18:306–360. 6.PrattW.B.(1998)ProcSocExptlBiolMed.217:420–434. 7.WhitesellL.,etal.(1994)ProcNatlAcadSciUSA.91:8324–8328.

ProductImages

SDS-PageofhumanHSP90Alphaprotein(SPR-101).Lane1:MolecularWeightLadder(MW).Lane2:HumanHSP90alphaprotein(SPR-101).

ProductCitations(8)

ATPaseactivityassay

ExperimentalAnti-InflammatoryDrugSemapimodInhibitsTLRSignalingbyTargetingtheTLRChaperonegp96

Wang,J.,Grishin,A.V.andFord,H.R.(2016)JImmunol.196(12):5130-7.

PubMedID:27194788Applications:ATPaseactivityassay

TherapidanddirectdeterminationofATPaseactivitybyionexchangechromatographyandtheapplicationtotheactivityofheatshockprotein-90.

Bartolini,M.,Wainer,I.W.,Bertucci,C.andAndrisano,V.(2012)JPharmBiomedAnal.73,77-81.

PubMedID:22497853Applications:ATPaseactivityassay

ChaxamycinsA–D,BioactiveAnsamycinsfromaHyper-aridDesertStreptomycessp.

Rateb,M.E.etal.(2011)JNatProd.74(6):1491-1499.

PubMedID:21553813Applications:ATPaseactivityassay

OtherCitations

Extracellularheatshockprotein90αmediatesHDM-inducedbronchialepithelialbarrierdysfunctionbyactivatingRhoA/MLCsignaling.

Dong,H.M.etal.(2017)RespirRes.18(1):111.

PubMedID:28558721Applications:FunctionalAssay

TargetingtheHsp90C-terminaldomaintoinduceallostericinhibitionandselectiveclientdownregulation.

Goode,K.M.etal.(2017)BiochimBiophysActa.[Epubaheadofprint]

PubMedID:28495207Applications:DARTsAssay

OxidationandinteractionofDJ-1with20SproteasomeintheerythrocytesofearlystageParkinson"sdiseasepatients.

Saito,Y.etal.(2016)SciRep.6:30793.

PubMedID:27470541Applications:FunctionalAssay

IdentificationofnewFGF1bindingpartners-Implicationsforitsintracellularfunction.

Bober,J.etal.(2016)IUBMBLife.68(3):242-51.

PubMedID:26840910Applications:SurfacePlasmonResonanceSpectroscopy

CoexposuretoMercuryIncreasesImmunotoxicityofTrichloroethylene.

Gilbert,K.M.,Rowley,B.,Gomez-Acevedo,H.andBlossom,S.J.(2011)ToxicolSci.119(2):281-292.

PubMedID:21084432Applications:WesternBlotControl

品牌介绍

StressMarq Biosciences Inc.位于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究。我们有强大的国际经销商网络，主要为私人和公众客户提供经我们多次试验成功的试剂，服务范围遍及全球40多个国家。我们公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。通过定位好以上四个领域，研究人员能够运用研究相关的整套试剂工具，将研究产品重点放在热休克蛋白70和90（HSP70和HSP90）两个核心领域。产品主要包括ELISA试剂盒、抑制剂、蛋白质（包括无内毒素制剂，而非低内毒素制剂）以及经过高级验证的抗体，产品在全球范围内均有销售。 StressMarq因其试剂验证质量过硬，跻身为高端公司。研究人员能放心使用抗体产品，因为本产品将具有免疫印迹（WB）、免疫沉淀、组织染色技术的功能，如免疫组织化学（IHC）和免疫细胞化学（ICC）。本公司提供氧化应激产品，如8OHdG（DNA受损）ELISA试剂盒，同时还提供专门的抗体，适用于非定量技术，如免疫组化。在免疫组化中，组织的目标可视化更为重要。除了提供用于进一步研究的相关工具外，StressMarq还提供新的尖端研究工具，用于开发新的生物项目，包括全球独一无二的α B晶体蛋白ELISA试剂盒（现在是公认的乳腺癌标志物）以及热休克同源蛋白70（Hsc70）ELISA试剂盒。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域，前者包括当前热门的核心领域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括当前热门的核心领域：ENaC、NCC和NKCC2以及主要水通道蛋白载体。

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